Chili pepper hot hands have a burning sensation, generally can be relieved by rubbing alcohol, applying vinegar and other methods, capsaicin is dissolved in alcohol and vinegar. The main reason why chili peppers are hot hands is because chili peppers contain a large amount of capsaicin, the most important substance is capsaicin in capsaicin capsaicinoids, cutting chili peppers when touching the skin, capsaicinoids will lead to blood vessel microtransparency, resulting in redness and heat of the skin. At the same time hands contain rich sensory nerves, including pain nerves, when capsaicin stimulates the pain nerves, it will cause the said burning sensation. Common treatments include rubbing with white wine or vinegar; capsaicin can be dissolved in ethanol or acetic acid, but is difficult to dissolve in water. Therefore after cutting the chili pepper, you can remove some of the capsaicin or capsaicinoids by applying white wine or vinegar to your hands to reduce the discomfort. Alternatively, cold compresses can be applied to the affected area to ease the discomfort.