Persistent ground-glass nodules may be lung cancer, but they can also be caused by non-cancerous factors such as infections and need to be analyzed on a case-by-case basis. Frosted glass nodules in the lungs are mostly lesions detected by imaging tests, such as chest CT. Both benign and malignant factors can cause ground-glass nodules in the lungs. If the lesion is characterized by burr sign, non-smooth edges, and rapid increase in size in a short period of time, it is more likely to be lung cancer, and should be diagnosed by pathological examination in a timely manner. In addition, non-cancer factors can also lead to ground-glass nodules, such as lung infection, pulmonary tuberculosis, tuberculosis and other causes. Therefore, ground-glass nodules are only an imaging manifestation, but whether they are cancerous or not requires puncture biopsy or PET-CT to determine the benign or malignant nature of the nodules when the risk of puncture is too high to be performed.