Pimples at the junction of cheeks and neck belong to acne, which is related to Propionibacterium acnes infection and abnormal sebaceous gland secretion and discharge, etc. It can be treated by general treatment, topical medication, oral medication, phototherapy and other measures. 1. General treatment: Wash your face with water or suitable cleansing products to remove oily secretions in time, but avoid excessive washing. Eat and drink regularly, keep bowel movement smooth, prevent constipation, avoid staying up late. 2. Topical medication: Adapalene gel, retinoic acid ointment and other anti-acne medications, along with erythromycin ointment, fusidic acid cream and other antibiotic medications. 3. Oral drug treatment: take tetracycline such as minocycline and other antibiotics or isotretinoin soft capsule, high androgen performance of women can take ethinyl estradiol cyproterone, spironolactone and other drugs. 4. Phototherapy: commonly used methods include LED blue light, red light, photodynamic and other measures. Cheek neck junction acne is recommended to first go to the hospital for examination, drugs need to be used under the guidance of a doctor.