Acromegaly is the common name for patients with motor neuron disease, a disease in which motor neurons are damaged and progress gradually. Clinically, patients mainly exhibit muscle weakness and muscle atrophy. At present, the etiology and pathogenesis of motor neuron disease are not very clear, and there is a lack of specific clinical treatment and methods. Treatment is symptomatic, including nutrition, management of the intestinal tract and urinary tract, respiratory support and psychological aspects of the integrated approach to treatment. Clinically used drugs to delay the disease, such as riluzole, edaravone, etc., can not be cured, and most die of respiratory muscle paralysis or lung infection. Patients with acromegaly are advised to use medication under the guidance of a physician, and to ensure nutritional intake and strengthen nursing care in daily life.