Whether high creatinine is a kidney disease or not mainly depends on the cause of creatinine increase. If it is caused by physiological reasons such as higher muscle content or eating more meat, it is not kidney disease; if it is caused by pathological reasons such as acute kidney injury or chronic renal insufficiency, it is kidney disease. 1. Physiological reasons: some patients’ creatinine elevation may be caused by their high muscle content, or eating more meat and exercising more, if there is no abnormality in urine routine and ultrasound of the urinary system, and creatinine may return to normal after adjusting the lifestyle, which is not a kidney disease. 2. Pathological reasons: acute kidney injury caused by various reasons, or glomerulonephritis, diabetic nephropathy, hypertensive renal damage and other diseases leading to chronic renal insufficiency, may lead to creatinine increase, this case is considered to be nephropathy, and need to be treated according to the cause. If patients find that the creatinine is elevated, it is recommended to go to regular hospitals in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.