Facial paralysis is medically known as facial nerve paralysis, facial paralysis with distorted mouth due to different causes of different medications, the main medications are hormones, nutrients, anti-inflammatory and anti-viral drugs, etiology of the treatment, etc. There are a lot of reasons that cause damage to the facial nerve, for example, facial cold, viral infections, inflammation, stroke, tumors, and so on. Facial nerve paralysis can be divided into “peripheral facial paralysis” and “central facial paralysis”. When there is a distortion of the mouth, the first thing to do is to differentiate between the two, both of which can be manifested as crooked corners of the mouth and the inability to puff out the cheeks. The difference is that peripheral facial palsy may also present with inability to close the eyes on one side and loss of headlines, while central facial palsy has symmetrical headlines on both sides. 1. When facial paralysis appears suddenly, accompanied by other symptoms such as dizziness, headache, numbness and weakness of limbs, unsteady walking, etc., the elderly or people with vascular risk factors such as diabetes mellitus, hypertension, dyslipidemia or heart disease need to be on high alert for the possibility of stroke. Further cranial CT or magnetic resonance examination is needed to clarify the diagnosis and exclude infections, tumors and other causes. Then, targeted treatment should be carried out for the specific causes of stroke, infection and tumor. 2. When the examination reveals peripheral facial paralysis without other accompanying symptoms and without the above vascular risk factors, it is most likely to be facial neuritis, which is mainly due to ischemic damage of the facial nerve caused by cold and viral infections, etc. The prognosis of the disease is generally good after antiviral treatment (e.g., acyclovir), hormone treatment (prednisone), nutritive nerve treatment (e.g., methylcobalamin), and rehabilitation treatment (acupuncture, tui-na, and massage, etc.). The occurrence of mouth is crooked should be promptly seek medical treatment by a specialist to determine the cause of treatment. Blind self-medication should be avoided.