Chicken skin refers to perifollicular keratosis, vitamin A cream has some therapeutic effect on perifollicular keratosis, the effect is slow, need to adhere to the medication. Keratosis pilaris may be related to vitamin A deficiency, congenital factors and other factors. It manifests itself as small papules centered on hair follicles on the limbs, which are rough to the touch, and is a skin disease with abnormal keratinization. Vitamin A acid cream can regulate the abnormal keratinization of hair follicles, induce epidermal hyperplasia and remove keratin plugs. It is suitable for perifollicular keratosis, furuncle, common acne and so on. Therefore, Retinoic Acid Cream can improve the symptoms of perifollicular keratosis pilaris. Adverse effects of retinoic acid cream include symptoms of skin irritation. The drug is contraindicated in the third month of pregnancy, during breastfeeding, and for those who are allergic to the product. The application of retinoic acid cream to remove chicken skin should be rationalized under the supervision of a doctor.