Multi-system atrophy, often manifested as autonomic dysfunction, Parkinson’s syndrome and cerebellar ataxia. There is no specific treatment for this disease, and the main symptomatic treatment is for autonomic dysfunction and Parkinson’s syndrome. A systematic treatment program can be proposed in combination with the doctor’s clinical diagnosis and treatment experience. Postural hypotension suggests non-pharmacological treatments such as compression stockings, etc. When the effect is not satisfactory, pharmacological treatments such as midodrine can be chosen. Voiding dysfunction can be improved by using drugs such as oxybutynin to improve the symptoms of urethral spasm; in patients with Parkinson’s syndrome, levodopa is effective in a small number of patients. Finally, the psychological cognitive function needs to be treated, such as giving nutritional brain cells, anti-anxiety, antidepressant drugs with intelligent rehabilitation, psychological rehabilitation treatment.