Patient: gonadal dysgenesis (chromosome 45X0) treated with Kinsey growth hormone from the age of 8 until earlier this year, now 16.5 years old and 151cm tall, but still not on estrogen or other medication to promote secondary sex characteristics One doctor suggested to stop taking the medication now and let her grow naturally until her epiphysis closes, then take estrogen-based medication. Another doctor said that she should be treated as soon as possible, otherwise she will be too big to be treated. I am very conflicted and would like to ask Dr. Tian what should I do? How should I treat it? How should I use the medication? Thank you! The metacarpal epiphysis of both hands and the distal epiphysis of the stony ulna have appeared, and the corresponding epiphyseal cartilage plate has not closed. The distal epiphysis of the right femur and the proximal epiphysis of the fibula have appeared, and the corresponding epiphyseal cartilage plate has not closed; the epiphyseal cartilage plate of the anterior cervical tuberosity has closed. The bone age was equivalent to 14-17 years. The bones of both hands are osteoporotic, the fourth metacarpal bone is shortened, and the metacarpal bone sign is positive. This is the skeletal age photograph taken in February of this year, which indicates that one ovary, the primordial uterus, and the chest are not developed. It is best to meet with the doctor directly to understand the situation before giving a specific, detailed treatment plan.