Short-term use of benzocaine condoms generally has no side effects, but long-term use may inhibit local nerves, leading to decreased local sensation and, in severe cases, may lead to impotence and premature ejaculation in men, and may also cause inflammatory reactions in the vagina and cervix of women, with abnormal leucorrhea and odor. Benzocaine is a surface anesthetic that reduces male glans sensitivity when in contact with the penis. Short-term use can delay male ejaculation time, but men should not rely on benzocaine condoms if they have symptoms of premature ejaculation, as this may aggravate the symptoms. Effective treatment should be carried out for the disease as early as possible, mostly clinically through drugs such as alpha1 adrenergic receptor blockers, or through surgical methods such as dorsal penile nerve selective excision. Patients who have sexual dysfunction due to psychological problems can improve their symptoms through psychotherapy. In addition, it should be noted that people who are allergic to benzocaine need to avoid using benzocaine condoms to avoid local itching, allergic dermatitis, and even anaphylaxis. If adverse reactions occur during use, they should be removed promptly to avoid serious adverse reactions, and if the symptoms are serious and do not subside, they should also go to the hospital promptly.