The human sensory system has a superficial sensory system and a deep sensory system. Walking with a sensation of stepping on cotton affects the deep sensory system of the human body, and the most common cause is peripheral nerve damage caused by metabolic factors. The most common causes are diabetes, vitamin B12 deficiency, alcoholism, drugs, heavy metal poisoning and toxic gases on the peripheral nerve deep sensory impact, deep sensory impact will appear walking like stepping on cotton feeling. If this symptom occurs, we should actively remove the original disease, actively treat diabetes, vitamin B12 deficiency, stop drinking, and avoid exposure to some toxic substances. At the same time, you can take oral medications for peripheral nerve nutrition, such as vitamin B12 and B1.