The treatment of metabolic acidosis includes the following points: 1, etiological treatment, corresponding treatment for the primary disease, such as patients with primary shock. At this time, it is necessary to carry out anti-shock treatment, including replenishment of blood volume, as well as the use of vasoactive drugs such as antihypertensive drugs, and severe infections can be anti-infective treatment; 2, the treatment of acidosis, according to the condition of the common use of sodium bicarbonate alkali supplementation treatment. If the patient’s cardiac insufficiency, it is necessary to control the speed and amount of alkali supplementation; 3, the treatment of organ function, according to the damage or organ failure organs, need to carry out the corresponding protection therapy.