Swelling of hands after six months of colon cancer surgery may be caused by poor blood circulation due to prolonged bed rest after operation, insufficient nutrition intake and large amount of fluids transfusion after operation. 1. Poor blood circulation due to prolonged bed rest after operation: after operation, due to the pain of wounds, unwillingness to do simple activities, failure to do proper exercise during the recovery period, prolonged bed rest, poor blood circulation, the symptom of swollen hands and feet will appear. 2. Insufficient nutritional intake and large amount of postoperative infusion: insufficient nutritional intake after surgery leads to the emergence of hypoproteinemia, the decrease of colloid osmotic pressure in blood vessels, and large amount of water extravasation leads to edema; and relevant infusion treatment after surgery leads to local blood vessel damage and causes edema. For those who have edema of hands after colon cancer surgery and the symptoms worsen after observing for a period of time, it is necessary to consult doctor in time and improve relevant examination under doctor’s guidance to make a clear diagnosis and avoid deterioration of the situation.