It is possible for a microscopic renal lesion to remain non-recurrent for the rest of one’s life, but recurrence is clinically possible in most cases. Whether it is prone to recurrence is affected by hormone sensitivity, infection and age, and cannot be generalized. 1. No recurrence: microscopic nephropathy can only be observed under the electron microscope fusion of glomerular peduncles, and the renal lesions are relatively mild. The vast majority of microscopic lesion nephropathy is sensitive to hormone therapy, and diuresis begins about 10 days after hormone use, with negative urine protein and eventual remission after several weeks. The cure rate in pediatric patients is relatively high compared to adults. After recovery, pay attention to diet and prevention of infection, may not recur for the rest of your life. 2. Relapse: Hormone-insensitive type needs immunosuppressant combined with hormone therapy, such as tacrolimus combined with prednisone, when the hormone is reduced at the late stage of treatment or when the body is infected, the glomerulus is very susceptible to damage by pathogens and the immune system destruction and injury, which will lead to relapse of the disease. When suffering from microscopic lesion nephropathy, you need to adjust the medication according to your condition under the doctor’s guidance, check the renal function and urine protein regularly, and pay attention to exercise to enhance immunity and prevent infection to reduce the chance of recurrence. It is recommended that patients go to regular hospitals in time to determine the specific treatment plan under the guidance of the doctor, and actively cooperate with the treatment to avoid the deterioration of the condition.