Thyroid peroxidase antibody is a more sensitive indicator for detecting autoimmune thyroid disease, the normal value should be <60IU/ml. Thyroid peroxidase antibody is greater than 1000IU/ml, which may be caused by diseases, such as hypothyroidism, autoimmune thyroiditis, etc., and need to be treated according to the situation. 1. Autoimmune thyroiditis: if the patient’s thyroid peroxidase antibody is greater than 1000IU/ml, it is necessary to further improve the thyroid function and thyroid ultrasound examination, if the thyroid function and thyroid ultrasound are normal, usually there is no need to be treated, and regular rechecking can be done. 2. Drug treatment: hypothyroidism caused by autoimmune thyroiditis and thyroid destruction caused by surgery may have thyroid peroxidase antibody greater than 1000IU/ml and hypothyroidism. This treatment is mainly medication, such as levothyroxine tablets. Patients are reminded that if their thyroid peroxidase antibodies are greater than 1000IU/ml, it is recommended to consult a doctor for examination and confirm the diagnosis and treatment under the guidance of a specialist.