The night to sleep to 2 to 3 o’clock heart pain mouth is also bitter may be related to acute gastritis, duodenal ulcer, reflux esophagitis and so on. 1. Acute gastritis: when the patient suffers from acute gastritis, it will easily lead to more gastric acid secretion, stimulate the gastric mucous membrane, the phenomenon of sleeping at night to 2 to 3 o’clock pain in the heart and mouth is bitter. 2. duodenal ulcer: if the patient has duodenal ulcer, it will be easy to appear preprandial pain, night pain, etc., is mainly abdominal pain, will be involved in the heart, appearing at night to sleep to 2 to 3 o’clock heart pain and mouth bitter situation. 3. Reflux esophagitis: If the patient suffers from reflux esophagitis, it will easily lead to the acidity of the stomach contents of the esophagus caused by irritation, causing esophageal inflammation, erosion, and so on, and appear to sleep at night to 2 to 3 o’clock pain in the heart and the mouth is still bitter condition. If the patient has heartburn and bitterness when sleeping between 2 and 3 o’clock at night, he or she should go to the hospital immediately to see a doctor, who will give him or her the right treatment after clarifying the cause of the disease.