A macrosomia is not a 4D ultrasound; a 4D ultrasound is a type of macrosomia. The macro-anomaly examination includes NT examination at 11-14 weeks of pregnancy, Down’s screening at 15-20 weeks of pregnancy as well as amniocentesis, non-invasive DNA, three-dimensional and four-dimensional ultrasound examination. Four-dimensional ultrasound examination belongs to one of the major types of malformations and is usually performed during the 22-26 weeks of pregnancy. Through four-dimensional ultrasound examination, it can understand whether there are malformations in the development of the fetus, such as congenital heart disease, cleft lip and palate, spina bifida, hydrocephalus, or abnormal development of the limbs, etc. Moreover, it can dynamically understand the situation of the fetus in the uterus and can see the activities of the fetus inside the uterus in an all-around and clear way. During pregnancy, it is necessary to do a close job of pregnancy test, according to the different time of pregnancy, under the guidance of the doctor to choose the appropriate maternity program for examination.