Membranous nephropathy is usually marked by a decrease in urine protein, in addition to the reduction of hematuria, edema, hypertension and other symptoms. Membranous nephropathy is one of the most common causes of nephrotic syndrome in adults, and the main sign of improvement of this disease is the reduction of urine protein, after treatment, it can effectively reduce antibody-mediated damage to the podocytes and glomerular filtration barrier damage, and then proteinuria, hematuria, edema, hypertension and other clinical manifestations are gradually controlled and improved. Even if the urine protein becomes negative, it only indicates that the condition has been controlled to a certain extent, at this time, it is still necessary to carry out regular drug treatment and regular follow-up review, specific recommendations for hospitals, follow the doctor’s guidance.