Pancreatic follicular cell carcinoma is a malignant tumor that is relatively rare, accounting for only 1-2% of pancreatic exocrine tumors. The mass tends to be large in size, soft in texture and clear in boundary, and the treatment is mainly based on surgery, supplemented by chemotherapy (e.g. gemcitabine, fluorouracil, mitomycin, etc.) and targeted therapy (e.g. bevacizumab, cetuximab, and erlotinib, etc.), among pancreatic cancers, the effect of surgical treatment and the prognosis is slightly better than that of the common ductal adenocarcinoma of pancreas, comparatively speaking. Pancreatic follicular cell carcinoma is a pathological staging of pancreatic malignant tumors, which is a low-grade malignancy among pancreatic tumors, and needs to be treated aggressively. The treatment plan needs to be decided according to the pathological staging, the patient’s physique, and whether the tumor has any proximal metastasis or distant metastasis. If the recurrence is localized in the pancreas, it is suggested that the localized pancreas can be resected, or the pancreas can be completely removed, and the surgical patients with more metastatic sites usually can not be operated for treatment. It is recommended to see a traditional Chinese medicine practitioner for diagnosis and treatment, and take oral Chinese medicine for treatment. When malignant tumors of the pancreas are found, due to the generally high degree of malignancy and poor prognosis, it is recommended to consult the General Surgery Hepatobiliary Surgery Department of regular hospitals to choose a reasonable treatment plan. For people with family history, alcoholism, obesity, pancreatitis and other high-risk groups, they should check their pancreas regularly, so as to achieve “early detection, early diagnosis, early treatment” and improve the survival rate.