Cholangiocarcinoma 5cm*5cm*4cm belongs to larger cases. Generally speaking, cholangiocarcinoma is more insidious in the early stage and does not show obvious discomfort symptoms. Therefore, most patients are found late, so the prognosis is poor. And cholangiocarcinoma 5cm*5cm*4cm belongs to larger tumors, which indicates that the condition may enter into middle or late stage, and even the cancer cells have spread. For this condition, if not treated in time, it will threaten the safety of life. When the size of cholangiocarcinoma is 5cm*5cm*4cm, radical resection surgery can be performed in time according to the actual condition. It should also be noted that routine drainage is usually not recommended before surgery, so as not to increase the risk of surgery. After surgery, a reasonable follow-up program should also be formulated according to the pathological examination to understand the progress of the disease in real time. For patients who are inoperable, chemical drugs should be used under the guidance of doctors to delay the disease, commonly cisplatin and oxaliplatin. At the same time with radiotherapy to inhibit limited metastatic foci. To summarize, cholangiocarcinoma is more life-threatening, especially when it is already 5cm*5cm*4cm in size, it is more necessary to take treatment measures as early as possible without further delay.