The way to get rid of rotting corners of the mouth quickly is to use different medicines to treat the cause of the disease, including supplementing nutrients, applying anti-infective drugs, removing allergens, avoiding trauma and so on. 1. Supplementation of nutrients: for a large number of lack of trace elements or lack of water and other nutrients leading to rotting corners of the mouth, you need to replenish a lot of water, as well as supplementation of multivitamins and other nutrients, usually pay attention to the corners of the mouth skin moisturizing, as much as possible to eat some fruits and vegetables. 2. Application of anti-infective drugs: for bacteria, viruses and other pathogenic microorganisms leading to rotting corners of the mouth, you need to apply gentamycin ointment or acyclovir ointment and other medicines to carry out the treatment, and pay attention to keep the corners of the mouth skin hygiene and dry. 3. Remove allergens: for contact with mango, lobster, crab and other allergenic substances lead to skin allergic reactions at the corners of the mouth, you need to apply chlorpheniramine maleate, glycerite and other drugs to carry out anti-allergy treatment, and at the same time, try to avoid re-exposure to allergenic substances in order to quickly eliminate the rotting corners of the mouth. 4. Avoid trauma: for incorrect occlusal relationship, bad restorations, hard object damage and other factors lead to skin breakage at the corner of the mouth, you can use saline wet compresses and apply povidone-iodine and other drugs to promote wound healing, so as to quickly eliminate the rotting corners of the mouth. Drugs should be used under the guidance of a physician.