There are two general reasons for non-healing wounds after open heart surgery, systemic factors and local factors. Systemic factors include patients with diabetes, malnutrition, autoimmune diseases, and liver and kidney insufficiency. Local factors are mainly wound redness and swelling, foreign body reaction, and skin infection. For poor wound healing, if it is simply redness and swelling of the skin without fluctuating sensation, the patient is first advised to go to a specialist hospital for treatment first. Patients are not advised to change the medication at home by themselves, because it is possible that a simple redness and swelling of the skin at the beginning, but due to improper treatment, it will cause the infection to worsen and there may be pus. For more specific people, such as those with diabetes or malnutrition, liver and kidney insufficiency, treatment should also be done for the underlying disease because, for example, diabetes, if the blood sugar is not well controlled, it will aggravate the infection. For malnutrition and low protein, the first step is to supplement protein, because protein synthesis is needed for wound recovery. For liver and kidney insufficiency, drugs to improve liver function are also used. The condition of the wound is usually assessed first when changing the medication. If it is a foreign body reaction or fat liquefaction, foreign body should be removed and exudate should be drained. If it is obvious purulent secretion, the secretion should also be left for culture appropriately, and antibiotics can be selected later according to the culture result.