Thyroid nodule with unclear border is considered to be nodular goiter, thyroid cancer and other diseases, different causes, different treatments, need to go to the hospital for further examination to confirm the diagnosis, if it is a benign lesion such as nodular goiter, it can be treated by regular review, medication, surgery and other treatments; if it is a malignant lesion such as thyroid cancer, it needs to be treated by surgery, radiotherapy, medication and other treatments. 1. Nodular goiter: on the basis of simple goiter, one or more nodules are formed by gradual compensatory hyperplasia of the gland, which may also lead to unclear boundary of thyroid nodules. Asymptomatic people may not need to undergo treatment, and regular checkups in the hospital are sufficient. If nodular goiter is clearly caused by iodine deficiency, potassium iodide can be taken orally, and if there is an indication for surgery, thyroidectomy is needed, and levothyroxine tablets can be taken for those who have postoperative or low thyroid hormone. 2. Thyroid cancer: Thyroid cancer can also lead to thyroid ultrasound showing nodules with poor borders, accompanied by solid hypoechoicity, microcalcification, etc. Patients can undergo surgical resection as prescribed by the doctor. Patients can undergo surgery to remove the thyroid gland and lymph node dissection as prescribed by the doctor, and can be treated with radionuclide 131I. After surgery, patients should also take levothyroxine tablets for the rest of their lives. It is recommended that patients with unclear borders of thyroid nodules under the guidance of the doctor for further examination to clarify the nature of the nodules and then targeted treatment.