Homocysteine is an intermediate product of amino acid metabolism in the body and can be metabolized in the body under normal circumstances, but there are abnormal reasons that may cause it to accumulate in the body and not be metabolized properly. High homocysteine can have adverse effects on the body and is an important risk factor for cardiovascular disease, and may also trigger hypertension and stroke, so it needs to be actively controlled. There are many reasons for high homocysteine, including genetic factors, nutritional imbalance, disease factors and drug factors. 1. Genetic factors: Some people are born with a lack of enzymes that can convert homocysteine, which leads to high homocysteine levels. 2. 3, disease factors: renal insufficiency, hypothyroidism, psoriasis, malignant tumors and other diseases can lead to elevated homocysteine; 4, drug factors: carbamazepine, methotrexate, metformin can lead to elevated plasma homocysteine levels; 5, other: poor dietary habits can also lead to elevated homocysteine, such as high-fat diet. It is recommended to adopt a healthy lifestyle, eat less large fish and meat, and eat more green vegetables, beans, cereals and other ingredients rich in folic acid and B vitamins, or consider taking oral folic acid to supplement. In addition, it is important to strengthen exercise, control weight, quit smoking and alcohol, and improve poor lifestyle to lower homocysteine levels.