Plexiform neurofibromas are common benign tumors whose lesions are generally not serious, but have a high probability of recurrence and are more difficult to remove completely. Plexiform neurofibromas generally grow on nerve fiber bundles. Neurofibromas are slow-growing, distributed at one or more peripheral nerves, and tend to form multiple tumors. If the tumor grows on the surface of the body, it can be observed as multiple, spherical masses of different sizes, which are tough, smooth and movable when touched. And it can leave pigmentation in the local area, such as multiple cafe au lait spots, mostly occurring in bilateral armpits and bilateral inguinal area, which usually do not have a relatively big effect on the organism. Plexiform neurofibroma can generally be treated by surgery. Although plexiform neurofibroma is a benign tumor, because it grows in the nerve area, it is more difficult to remove it completely by surgery, or because of the fear of affecting the nerve function and retaining part of the nerve fibers, which makes the tumor cannot be completely removed, and the tumor is prone to recurring after surgery. It is recommended that patients suffering from plexiform neurofibroma should seek medical treatment in time and under the guidance of doctors.