If squamous cancer of upper esophagus has not metastasized, surgical treatment, radiotherapy and targeted therapy can be chosen according to the size of the tumor and physical fitness of the patient. If upper esophageal squamous carcinoma has not metastasized and the tumor is small and the patient is in good physical condition, the tumor can be completely removed by surgery under the guidance of professional doctors. If the tumor is large and the patient is unable to tolerate surgery, radiotherapy and targeted therapy can be used to shrink the tumor lesion and slow down the progress of the disease. Common chemotherapeutic drugs include cisplatin, cyclophosphamide, fluorouracil and so on, and targeted drugs include cetuximab, gefitinib and so on. The drugs are recommended to be used in accordance with the doctor’s instructions, the emergence of adverse reactions in time to consult the doctor, drug allergy is prohibited. Therefore, after finding squamous carcinoma without metastasis in upper esophagus, it is necessary to actively cooperate with doctors to receive standardized treatment and improve the prognosis of the disease.