Urticaria is difficult to cure and is not directly related to whether the patient takes medication or not. Urticaria is a self-limiting disease, but it is difficult to be cured, mostly recurring or prolonged; some patients will be cured after temporarily removing the triggers, but will still recur after re-exposure to the triggers. Therefore, whether urticaria can be cured is not directly related to whether the patient takes medication or not, but actively cooperate with the doctor’s treatment can control the condition. Clinical urticaria, often applied to loratadine, cetirizine and other antihistamines, for antihistamines ineffective chronic urticaria, if necessary, can be combined with immunosuppressants such as cyclosporine, or omalizumab and other biological agents. It is recommended that patients with urticaria be treated with medication under the guidance of a physician, and not to use medication indiscriminately, increase or decrease the amount of medication without authorization.