The best way to solve the problem of large pressure difference is to find the cause of the disease, such as aortic valve insufficiency, hyperthyroidism, atherosclerosis, etc., and treat it with drugs such as hydralazine and methimazole. 1. Aortic valve insufficiency: If the diagnosis of aortic valve insufficiency is confirmed by echocardiography and other examinations, if there are no symptoms and normal cardiac function, 1~2 years of follow-up can be done. However, if there is cardiac decompensation that limits activities, vasodilating drugs such as hydralazine can be taken, and valve replacement surgery can be performed if necessary. 2. Hyperthyroidism: If hyperthyroidism is diagnosed by thyroid function measurement, it is necessary to take antithyroid medication, such as methimazole, under the guidance of a doctor. 3. Atherosclerosis: it is necessary to have a light diet in daily life, increase exercise in moderation, and take lipid regulating and stabilizing drugs, such as aspirin and atorvastatin, if necessary. Large pulse pressure difference refers to the increase in the difference between systolic and diastolic blood pressure, the normal value of pulse pressure difference is 40mmHg, and if it is >60mmHg, it means that the pulse pressure difference increases. Increased pulse pressure needs to be examined under the guidance of a doctor to determine the cause of the disease, and the above medications need to be used under the guidance of a doctor.