Calf numbness is not necessarily a precursor to major diseases, may be neuropathy, vascular lesions, diabetic peripheral neuropathy and other causes. 1. Neuropathy: As the nerves in the calf are rich, they can innervate the sensory function of the muscles, and when the nervous system is affected, the corresponding innervated area will be affected, such as patients with lumbar disc herniation, which will compress the sciatic nerve, accompanied by symptoms of impaired mobility and so on. 2. Vascular lesions: when the patient has lower extremity venous thrombosis, lower extremity arteriosclerosis and other diseases, there will be vascular lumen occlusion, ischemia, causing numbness in the calf. 3. Diabetic peripheral neuropathy: when the patient suffers from diabetes mellitus, it may cause peripheral neuropathy, which can lead to numbness of the calves. It is recommended that patients go to the regular hospital in time, under the diagnosis of the doctor, according to the patient’s condition, targeted treatment.