The possible causes of positive hepatitis B virus e antibody and core antibody include two kinds, one is low level of hepatitis B virus infection, due to the problem of detection sensitivity, resulting in negative HBsAg test, which can be judged by high sensitive hepatitis B virus DNA test; one is that one has been infected with hepatitis B virus in the past, and is now in the period of recovery, with the hepatitis B surface antigen disappeared, but the hepatitis B surface antibody is not yet appeared. If the sensitivity of hepatitis B marker test is low, hepatitis B surface antigen is not detected, and hepatitis B surface antigen and hepatitis B viral DNA actually exist in the body, and the viral DNA can be detected by high-sensitivity hepatitis B viral DNA test, then it is the state of hepatitis B infection, which may be accompanied by liver function damage and liver fibrosis, and it is necessary to follow the doctor’s instructions to use drugs such as entecavir for treatment. If hepatitis B virus DNA is negative, liver function is normal, not accompanied by uncomfortable symptoms, hepatitis B virus e antibody, core antibody is positive on behalf of the hepatitis B virus has been infected, but due to medication or body immune clearance, the virus has been basically cleared, is currently in the stage of recovery of hepatitis B, generally not infectious. Therefore, it is recommended that the patient should consult the doctor in time and make a comprehensive judgment according to the specific symptoms, hepatitis B virus DNA and liver function tests.