Can married women with hepatitis B virus and hepatitis patients get pregnant and have children? The answer is yes, but it should be treated separately according to the specific situation. Acute hepatitis B patients after adequate treatment and conditioning, liver function indicators return to normal, hepatitis B virus antigen have turned negative, physical strength fully recovered, you can get pregnant. Hepatitis B virus carriers with long-term follow-up liver function is always normal, ultrasound examination does not have hidden cirrhosis, can be normal childbirth. Chronic hepatitis B patients with long-term stabilization can also get pregnant. In other words, as long as liver function is normal, there is no inflammatory activity in the liver, and there are no clinical symptoms, both carriers and patients can get pregnant. Some conditions are not suitable for pregnancy. If the disease is in the active phase of inflammation, feeling unwell (e.g. fatigue, loss of appetite, abdominal distension, discomfort in the liver area, etc.), and abnormal liver function (elevated transaminases, bilirubin, etc.), it is not suitable for pregnancy. If hepatitis has progressed to cirrhosis, it is best not to get pregnant; pregnancy is absolutely inadvisable in decompensated cirrhosis. The fetus after pregnancy will increase the load on the liver and aggravate the condition, which is not favorable to the mother and child. Can I get pregnant while taking medication? Because of the safety of the drug is extraordinary, so it is best not to get pregnant while taking the drug. According to domestic and international data, more information on the safety of taking the drug during pregnancy is lamivudine, if you have to get pregnant while taking the drug, lamivudine can refer to more information, the risk is very small, but it is not zero risk. Specifically, pregnancy is contraindicated in the following cases: ① Acute hepatitis B, liver function is obviously abnormal. ② long history of severe liver damage, liver biopsy confirmed cirrhosis, with obvious thrombocytopenia, hypersplenism and coagulation disorders. ③ Chronic hepatitis B with more obvious liver function abnormalities and large fluctuations, often accompanied by inverted protein ratio or hypoproteinemia. ④ Chronic hepatitis B with severe extrahepatic systemic manifestations, such as nephropathy and aplastic anemia. ⑤ Those who have had a history of pregnancy but terminated the pregnancy because the liver could not bear it. ⑥ Those with hepatitis B with obstetric and gynecological disorders who are not suitable for pregnancy. During pregnancy, is there any difference between pregnant women with hepatitis B and those without hepatitis? There are still some differences. First of all, don’t take drugs indiscriminately, some drugs will damage the liver. Don’t eat too much, so as not to form a huge fetus, huge fetus delivery with hepatitis pregnant women have more risk of hemorrhage than normal women. Generally, pregnant women can have a liver function test once during pregnancy, but pregnant women with hepatitis should have it done at least three times. Through the monitoring of liver function and other aspects, we can observe whether the pregnant woman can be competent for pregnancy, with a view to achieving the safety of mother and baby. If abnormal liver function is found, liver-protecting treatment should be actively carried out; at the same time, according to the level of HBV DNA replication, corresponding measures should be taken to control the condition and block intrauterine infection. Pregnant women suffering from hepatitis B should also undergo antiviral treatment. Except for those with severe conditions such as decompensated cirrhosis and severe hepatitis who need to terminate the pregnancy in a timely manner, most of them do not need to terminate the pregnancy, and can deliver naturally. As long as there are indications for antiviral treatment (active replication of hepatitis B virus, transaminases greater than two times the upper limit of normal value), appropriate antiviral drugs should be given. Hepatitis B has familial aggregation. However, hepatitis B is not a hereditary disease, and its familial aggregation is due to transmission rather than heredity. The so-called “mother-to-child transmission” of hepatitis B refers to the transmission of the virus from a pregnant woman who has hepatitis B or carries the hepatitis B virus in her body to her fetus or newborn during pregnancy or delivery. This mode of transmission, also known as vertical transmission, is the most important and threatening mode of hepatitis B transmission. Not 100% of pregnant women carrying the hepatitis B virus will transmit it to their fetus or newborn. Whether or not it leads to fetal or neonatal infection depends firstly on the degree of replication of the hepatitis B virus in the pregnant woman’s body and the genetic defects of the mother. If the pregnant woman is positive for the e antigen and has a high level of hepatitis B virus deoxyribonucleic acid (HBV DNA) in her blood, the rate of neonatal infection can be as high as about 90%; if the pregnant woman is negative for the e antigen and negative for the HBV DNA, the rate of infection will only be about 30%. Hepatitis B mother-to-child transmission is most common in labor and delivery, that is, in the delivery of the baby’s skin, mucous membrane abrasion or placental abruption, the virus in the mother’s blood through the rupture of the placenta, into the umbilical cord blood, and thus into the body of the newborn. What type of delivery method can be chosen at the time of the child’s birth to interrupt mother-to-child transmission? Some people believe that the use of cesarean section can block mother-to-child transmission; in fact, it is not common for babies to be directly infected through the placenta in the uterus prior to delivery, and newborns can only be infected if they come into contact with the mother’s blood during delivery when there is a rupture of the mother’s birth canal and a long duration of labor. Therefore, for pregnant women with the virus, it is best to give birth naturally, and cesarean sections are used only if natural delivery is dangerous or difficult. Another route is intrauterine transmission, in which the baby becomes infected with the hepatitis B virus through blood circulation in the mother’s body. This causes about 5% of infections. Then there is the close contact between the baby and the mother after delivery, which can also transmit the hepatitis B virus. Mother-to-child transmission can be effectively interrupted by administering Hepatitis B Immune Globulin (HBIG) and Hepatitis B vaccine to the newborn. Newborns are given HBIG as early as possible within 24 hours of birth, along with 10 μg of recombinant yeast or 20 μg of Chinese hamster oocyte (CHO) hepatitis B vaccine. Alternatively, one injection of HBIG can be given within 12 hours after birth, followed by a second injection of HBIG 1 month later, and a concomitant injection of 10 μg of recombinant yeast or 20 μg of CHO hepatitis B vaccine, with the second and third injections of vaccine (10 μg of recombinant yeast or 20 μg of CHO hepatitis B vaccine for each) given at intervals of 1 and 6 months, respectively. The preventive effect can reach more than 90%~95%. Breastfeeding by hepatitis B surface antigen-positive mothers does not increase the risk of infection in their infants, so as long as the newborn has been vaccinated with HBIG and hepatitis B vaccine within 12 hours of birth, breastfeeding is permitted, although breastfeeding should be temporarily discontinued if there is damage to the nipple.