Antiviral treatment for hepatitis B is expensive, with a course of treatment using any of the current antiviral regimens, the total treatment cost for medications plus tests is nearly$10,000 dollars. In order to utilize antiviral medications most effectively, it is important to time antiviral therapy well. The best time for antiviral therapy to be carried out is when HBVDNA is positive and ALT fluctuates repeatedly; in addition, some patients with cirrhosis, hepatitis B-infected patients with liver and kidney transplantation, and hepatitis B-infected patients with tumor chemotherapy and perioperative period can also be used. However, at present, some patients with normal liver function take self-medication in order to achieve the purpose of clearing hepatitis B virus, although the result of HBVDNA negative can be achieved in the early stage of treatment, but it will be elevated again after stopping the medication, and some of them will have viral resistance, and even when the patients really need antiviral treatment, they can’t choose the effective therapeutic drugs, which is a very undesirable practice! Moreover, there are some possible side effects of antiviral therapy itself, such as interferon has certain effects on thyroid function, blood sugar, cryptogenic mental illness, and inhibitory effect on blood; the effect of some new nucleoside antiviral drugs on fetus is not completely clear, and some drugs will cause patients’ renal function (Cr) abnormalities, increased serum creatine kinase (CK), and so on. Therefore, it is very wrong and dangerous for patients to buy drugs for treatment by themselves! Patients should only decide when antiviral treatment is really necessary after a detailed examination by a doctor.