Hepatitis B cirrhosis (referred to as hepatitis B cirrhosis) develops from chronic viral hepatitis B. After HBV infects the liver cells, due to the attack of immune cells in the body, it causes inflammation and necrosis of the liver cells, and scar tissues are gradually formed in the area of inflammation and necrosis, which leads to gradual hardening and deformation of the liver and thus develops into cirrhosis. Due to the strong compensatory function of the liver, there are often no obvious symptoms in the early stage (also called compensatory stage); complications such as upper gastrointestinal hemorrhage, hepatic encephalopathy, secondary infections, ascites, etc., are often seen in the late stage (also called decompensated stage). In patients with cirrhosis, the annual incidence of hepatocellular carcinoma is 3%-6%, so the prevention and treatment of hepatocellular carcinoma is very important. Can hepatitis B cirrhosis be cured? Hepatitis B cirrhosis patients can be controlled and stabilized as long as they have standardized treatment, regular checkups, and pay attention to rest and diet. With the continuous development and marketing of oral antiviral drugs, one pill a day can inhibit HBV replication and control liver inflammation. Cirrhosis was previously thought to be unrecoverable once it had occurred, but new research findings have shown that cirrhosis can also be reversed. Some anti-fibrotic drugs that are widely used nowadays, such as Fu Huayu capsule and Compound turtle shell soft liver tablet, have been proved to have certain efficacy in reversing liver fibrosis and treating cirrhosis. Therefore, as long as timely and correct treatment, Hepatitis B cirrhosis can be controlled, and most of the patients can live as healthy as normal people after treatment. Must cirrhosis be treated with antiviral therapy? Antiviral treatment is the most basic principle of hepatitis B cirrhosis treatment. Chronic hepatitis B patients with evidence of compensated or decompensated cirrhosis need antiviral treatment regardless of their ALT level, HBeAg status and HBV DNA level. Can antiviral medication be stopped when the disease improves? Hepatitis B cirrhosis cannot be stopped and must be taken for a long time. Antiviral therapy for chronic hepatitis B can only inhibit viral replication, but cannot completely eliminate the virus yet. Although the virological indicators become negative after using antiviral drugs, it only means that the viral load is lower than the lower limit of the current detection level, which does not mean that there is no hepatitis B virus in the body. There are often patients with chronic hepatitis B whose virological indexes have become negative and liver function has returned to normal, and their conditions have been relieved or even recovered as normal, but once the drugs are stopped, the virus will rebound immediately, resulting in a sudden aggravation of the condition, and very few of them will even develop into liver failure, which is life-threatening. Hepatitis B patients in the cirrhosis stage are even less able to withstand the rebound of drug withdrawal, which may directly lead to a significant decline in the quality of life or life-threatening once the disease progresses. In addition, stopping drug rebound will also make the virus produce drug resistance, increase the difficulty of re-treatment and increase the cost of treatment. Therefore, for patients with chronic hepatitis B, long-term antiviral treatment with potent, low-resistance drugs is the safest and most economical method. In addition, antiviral treatment is the foundation of antifibrosis treatment, long-term viral suppression is the only way to have a chance to reverse cirrhosis and improve the quality of life. Of course, if there are obvious adverse reactions during the course of treatment, such as deterioration of general condition, obvious myalgia, muscle weakness and other symptoms, or patients with obvious elevation of blood creatinine, creatine kinase or lactate dehydrogenase in laboratory tests, they should consult the doctor in time, and the doctor will determine whether it is necessary to stop the medication or switch to other antiviral drugs. How to do regular follow-up? Patients with hepatitis B cirrhosis have an increased incidence of hepatocellular carcinoma. They should be tested for alpha-fetoprotein and abdominal ultrasound at least once every 6 months, and if any abnormality is detected, they should immediately undergo enhanced CT or MRI scanning for early detection, diagnosis and treatment. Cirrhotic patients should also undergo gastroscopy or upper gastrointestinal x-ray imaging every 1~2 years to observe the presence of esophagogastric fundal varices and their progress. Laboratory tests for HBVDNA, liver function, and blood routine should be performed every 3 months to monitor antiviral treatment and liver function status. Patients with compensated cirrhosis, antiviral therapy can choose interferon and nucleoside (acid) analogs, the choice of interferon must pay attention to the adverse reactions and contraindications to interferon therapy; cirrhosis patients with decompensated stage, antiviral therapy can only choose nucleoside (acid) analogs, and it is best to choose potent low-resistant drugs tenofovir ester or entecavir treatment.