In working life, it is inevitable to have contact with the blood of hepatitis B patients, especially for medical personnel, being stabbed by needles injected to hepatitis B patients or being scratched by surgical blades happens from time to time, because there is contact with the blood, so the risk of this situation being infected is very high, and it is necessary to take precautions as soon as possible, according to China’s latest preventive guidelines, after accidental contact with blood and body fluids of hepatitis B virus infected patients, it can be handled as follows The following methods can be handled: 1. Serologic testing: Hepatitis B virus DNA, hepatitis B five indexes and liver function should be tested immediately and reviewed in 3 months and 6 months. 2.Active and passive immunization: If the hepatitis B vaccine has been administered and anti-HBs is known to be ≥10IU/L, no special treatment may be performed. If they have not received hepatitis B vaccine, or if they have received hepatitis B vaccine but anti-HBs <10IU/L or the level of anti-HBs is not known, they should be injected with hepatitis B immunoglobulin 200--400IU immediately, and at the same time, they should receive one injection of hepatitis B vaccine 20ug at different sites, and the second and third injections of hepatitis B vaccine (20ug each) should be given one month and six months later respectively.