Hepatorenal syndrome (HRS) refers to a series of serious complications such as renal failure and altered arterial circulation in patients with liver disease, especially chronic liver disease, when they develop severe conditions such as liver failure and portal hypertension. Hepatorenal syndrome mainly occurs in patients with compensated cirrhosis, especially hepatitis cirrhosis and alcoholic cirrhosis, etc. It may also occur in patients with severe liver diseases such as fulminant liver failure and hepatocellular carcinoma. If a patient develops hepatorenal syndrome, it can be troublesome to treat. However, for mild to moderate renal impairment, as long as it is actively treated, it can still be restored to the normal level. At present, there are four main methods to treat hepatorenal syndrome: drug treatment, surgical treatment (kidney transplantation), hemodialysis and so on. Among them, drug treatment mainly includes visceral vasoconstrictor drugs and so on. These drugs, when injected intravenously, can make the obviously dilated renal artery vasoconstriction, improve blood circulation and increase renal blood flow, thus improving renal function. As the patient’s renal function improves, the dose of the drug can be slowly reduced until it is stopped. However, the drug also has certain side effects. The most common are abdominal pain and diarrhea. This is because these drugs will not only contract the abnormally dilated renal artery blood vessels, but also cause the normal blood vessels in the abdominal cavity to contract. Once the blood vessels in the gastrointestinal tract are irritated, adverse reactions such as abdominal pain and diarrhea are likely to occur. In addition, patients with high blood pressure, if the blood pressure is usually not well controlled and unstable; after the use of such drugs, the blood pressure is likely to fluctuate. Of course, each patient’s physical condition is different, and there are individual differences in the occurrence of adverse reactions. Drug treatment of hepatorenal syndrome usually requires hospitalization for one to two weeks. During the treatment period, doctors will pay attention to two aspects in order to reduce the side effects of drugs. On the one hand, if a patient experiences abdominal pain or diarrhea after taking the medication, the doctor can adjust the time and frequency of injections to alleviate the patient’s discomfort; this ensures the effectiveness of the treatment and reduces the side effects of the medication. On the other hand, drugs must be stored at low temperatures because these drugs belong to peptides and are easily denatured when stored at too high a temperature. If the drug is denatured, a series of adverse reactions may occur. After one to two weeks of drug treatment, the kidney function of most patients can return to normal. However, the root cause of hepatorenal syndrome is liver disease, and these drugs can only improve kidney function, so the condition is easy to relapse. So in order to prevent relapse, what problems do patients need to pay attention to in their daily life? First, avoid infection. Avoid bacterial, viral, fungal and other pathogenic infections, especially lung and abdominal infections, because infections will aggravate the inflammation and burden of the liver, kidneys and other important organs, which will lead to relapse. Second, diet regulation. Eat a light diet, mainly soft food (such as porridge, noodles, etc.), do not eat greasy, hard food (such as fatty meat, nuts, etc.). In addition, attention should be paid to supplement protein (mainly high-quality protein), because low plasma albumin levels can easily lead to ascites. Third, exercise should be moderate. If the patient already has cirrhosis, then must avoid strenuous exercise, such as racing, boxing, playing basketball, etc.; can only do some health care exercise, such as walking.