Hand blisters should be handled according to the size of the blisters, rupture and other factors, for small blisters do not need special treatment; for large blisters, ruptured blisters should be pumping liquid, applying drugs. If the blisters are small and do not cause discomfort, they are usually not treated, and can be temporarily observed and the local skin cleaned and dried to prevent infection, and the blisters can be absorbed on their own. If the hand blisters are relatively large, it is difficult for the blisters to absorb on their own, you can go to the hospital in time, use a sterile syringe to puncture the blisters, draw out the liquid inside the blisters, and disinfected, such as applying iodine povidone or mupirocin ointment, and after a period of time, it can be restored to normal. As for the ruptured blisters or have formed erosion pus, you can apply local antibiotic ointment, such as mupirocin ointment, erythromycin ointment and so on. Hand grinding out blisters if the blisters are large, has ruptured, it is recommended to go to the hospital by a professional doctor to deal with, do not use their own arbitrary use of drugs.