Tetrodotoxin, also known as tetrodotoxin, is a neurotoxic substance that can cause poisoning when consumed, mainly manifesting as numbness, nausea, vomiting, headache and other symptoms, and in severe cases can lead to respiratory and cardiac arrest and death. The main principle of action of tetrodotoxin is to affect sodium metabolism, which can prevent sodium ions from entering the nerve cell membrane and then affect the function of the nervous system. The main toxic components of tetrodotoxin are the ovaries, liver, kidneys and other parts, but long after death, these toxins can enter the muscles, so that the muscles of tetrodotoxin are not toxic, but the internal organs of these toxins into the muscles of human consumption can also lead to death by poisoning. The toxicity of tetrodotoxin also changes in different seasons, for example, in early summer when tetrodotoxin is the largest, and in autumn and winter when tetrodotoxin is relatively small.