In its early stages, primary biliary cholangitis poses little or no threat to life expectancy. Primary biliary cholangitis is primarily an autoimmune liver disease that causes extensive hepatic ductal destruction and cholestatic liver stiffness, primarily due to the cholestasis that results, along with the development of anti-mitochondrial antibodies in the circulating blood, and non-suppurative inflammatory destruction of intrahepatic tubules. Primary biliary cholangitis early clinical symptoms for mild fatigue, intermittent itching, etc., mainly through methotrexate tablets, azathioprine tablets, cyclosporine soft capsules and other medications, comply with the doctor’s instructions for treatment, active treatment, generally will not have an impact on life expectancy. It is recommended to go to the regular hospital for inquiry and consultation, it is recommended to carry out treatment under the guidance of the doctor, and follow the doctor’s instructions to use medication, so as not to cause adverse reactions.