Interstitial colon is a condition in which the hepatic flexure of the colon enters between the liver and the diaphragm, resulting in a condition known as Interstitial Colon Syndrome, also known as Chilaiditi Syndrome. This condition is often associated with congenital abnormalities and acquired diseases, and needs to be managed in conjunction with clinical symptoms and under the guidance of a clinician. In the normal population, the gap between the liver and the diaphragm is small and the neighboring structures are dense, so that the colonic liver area does not enter into the corresponding gap. In some people, the liver moves downward (weak diaphragm, ligament laxity, etc.) or the liver atrophies (cirrhosis, etc.), causing the gap between the liver and the diaphragm to widen, which leads to the hepatic area of the colon to enter the corresponding gap, resulting in the appearance of interstitial colon. Most people do not have any symptoms per se and do not require much intervention, taking care to control their diet and avoiding foods with excessive gas production. A small proportion of the population may suffer from localized flatulence and restricted food evacuation, causing symptoms of pain and discomfort in the corresponding area, which can be surgically fixed if the pain is not tolerated. Interstitial colon once caused obvious right upper abdominal pain, colonic obstruction and other manifestations, the need for timely medical observation, under the guidance of clinicians for standardized treatment.