Highly differentiated gastric cancer is less malignant and can survive for a long time with a five-year survival rate of about 80% to 90% if treatment is timely. However, the specific situation should be evaluated according to the diagnosis stage, age, postoperative recovery and physical condition. Highly differentiated gastric cancer refers to gastric cancer with higher differentiation degree and less malignant degree. In clinical practice, five-year survival rate is generally used to assess survival. For patients with highly differentiated gastric cancer, the five-year survival rate of early lesions after surgery can be close to 95.0%, which is significantly higher than that of progressive gastric cancer. According to the clinical staging of advanced gastric cancer, the five-year survival rate of stage I is about 92.6%, stage II is about 76.2%, stage III is about 40.8%, and stage IV is about 6%. To summarize, the malignancy degree of highly differentiated gastric cancer is relatively low, and if diagnosed and treated at an early stage, the five-year survival rate of patients can be significantly improved. Therefore, it is recommended that patients maintain good living habits and go to regular hospitals regularly for gastroscopy and other screening programs so as not to miss the best time for treatment.