Prostate cancer bone metastasis pain treatment drugs include painkillers, radiotherapy and endocrine therapy, etc. The drugs need to be used in a standardized way under the guidance of doctors. Prostate cancer patients with bone metastasis indicate that they have entered the advanced stage, and their treatment mainly includes lesion-specific treatment and symptomatic treatment. 1. Treatment for lesions: endocrine therapy is the main treatment for patients with hormone-dependent prostate cancer with bone metastases; chemotherapy is one of the main treatments for hormone-resistant prostate cancer; molecular targeting therapy such as denosumab is an optional treatment; radiotherapy is valuable for relieving pain and treating metastatic foci and primary foci; and some patients can receive surgical treatment; 2. Symptomatic treatment: bisphosphonate phosphate, as the first-line drug for bone metastatic cancer, can effectively treat bone destruction and relieve bone pain; radiotherapy is also of great value in relieving bone pain; in addition, reasonable pain relief treatment is of great significance in improving the symptoms of patients. When bone metastasis occurs in patients with prostate cancer, different symptoms may occur, depending on the site of metastasis and the individual. It is recommended that patients go to the hospital for consultation in time and take specific treatment measures according to the doctor’s instruction. Please strictly follow the doctor’s prescription for medication, and do not use medication on your own.