Azilsartan and ali-sartan are both drugs belonging to the class of angiotensin II receptor antagonists, and they have the same mechanism for lowering blood pressure, but they are not the same kind of drug, and their molecular structures are different. Clinically, angiotensin II receptor antagonists are mainly used in the treatment of hypertension, by blocking the angiotensin II receptor, so that vasodilatation, to achieve the purpose of lowering blood pressure. Due to its ability to inhibit ventricular remodeling, it can be used to treat chronic heart failure as well as myocardial remodeling after myocardial infarction to improve prognosis. Angiotensin II receptor antagonists are long-acting antihypertensive drugs with a slow onset of action but long-lasting effects. The main adverse effects include dizziness, headache, panic, abdominal pain, diarrhea and loss of appetite. It should be noted that angiotensin II receptor antagonists are contraindicated in hyperkalemia, bilateral renal artery stenosis and pregnant women. Therefore, both azilsartan and alirosartan can be used in the treatment of hypertension, and both have similar adverse effects and contraindications, so patients can choose under the guidance of specialists.