Shivering and chills, chills after taking metformin may be due to adverse drug reactions, infections in the body itself, or a colder environment. 1. Adverse drug reactions: after taking metformin there may be an adverse reaction of hypoglycemia, the performance may be similar to shivering. It is recommended that the patient consult a doctor in time and adjust the dose of the drug according to the doctor’s instructions. 2. Infection: patients with upper respiratory tract infections, acute cellulitis and other infectious diseases may lead to increased body temperature and chills. 3. Cold environment: when the temperature is lowered to a certain degree, the human skeletal muscles will experience tremor contraction to help the body produce heat, and chills will occur in a cold environment. Metformin is used in patients with type II diabetes mellitus who are not satisfied with dietary control alone, especially those who are obese and with hyperinsulinemia. Adverse effects of this drug include nausea, vomiting, headache, and hypoglycemia. It is contraindicated in patients with hepatic and renal insufficiency, chronic cardiac insufficiency, heart failure, acute myocardial infarction, severe infection and trauma. This product is contraindicated in pregnant women. Chills after eating metformin should go to the hospital in time, clarify the cause of the disease, and carry out regular treatment according to the doctor’s guidance and recommendations, so as not to delay the condition.