With the increasing competition in our society, middle-aged and young people in first-tier cities need to stay up more and more frequently to finish their work, study and exams. However, a large number of studies in the last 2 years have shown that long-term late nights and chronic insomnia may lead to Alzheimer’s disease, and further confirmed by neuroimaging that less than 7 hours of sleep per day increases the abnormal protein deposition associated with progeria, and significantly worsens if less than 6 hours. With the damage and apoptosis of neurons in the brain, the accompanying sleep disorders become increasingly severe. About 34-82% of dementia patients will experience poor sleep, and poor sleep not only significantly reduces the quality of life of dementia patients and their families, but also further accelerates the decline of patients’ memory. Sleep disorders in Alzheimer’s disease also include difficulty falling asleep, increased nighttime awakenings, early awakening, punching and kicking during sleep, rolling out of bed, sleep walking disorder, nightmares, significantly increased daytime “napping” or napping, and the “sunset syndrome” that often occurs in patients with moderate to severe dementia “(a series of mood and cognitive changes at dusk, such as mood disturbances, anxiety, hyperactivity, and disorientation, lasting several hours or the whole night). Its pathogenesis is due to an acute lack of blood supply to the brain. (Although most of them can return to normal within a few hours or days, this acute lack of cerebral blood supply is often a precursor to cerebrovascular accidents and heart attacks, so it should not be taken lightly). Poor sleep quality is a common problem among middle-aged and elderly people, but it has not been given enough attention, and now there is even more evidence suggesting that sleep problems in young adults are also closely related to progeria. All of the above studies suggest that we should ensure adequate sleep duration and quality. Since sleep disorders often appear years or even more than a decade before clinical symptoms of dementia and Parkinson’s disease appear, if you or your family members are suffering from poor sleep, please seek early diagnosis and timely treatment so as to delay or even prevent the onset of dementia.