Which one is better, Duloxetine or Paroxetine, should be based on the patient’s own response to the drug to decide which drug is more suitable, can not be generalized, it is recommended to choose the right drug under the guidance of professional doctors. Duloxetine Hydrochloride and Paroxetine Hydrochloride are both medications used to treat anxiety and depression. Duloxetine hydrochloride is a selective dual-channel reuptake inhibitor of 5-hydroxytryptamine and norepinephrine, and paroxetine is a selective 5-hydroxytryptamine reuptake inhibitor. Adverse reactions to duloxetine hydrochloride include nausea, dry mouth, drowsiness, constipation, and decreased appetite. It is contraindicated in people who are allergic to the product and the ingredients contained in it, and in patients with untreated narrow-angle glaucoma. Combination with monoamine oxidase inhibitors is prohibited. It is contraindicated in pregnant and lactating women. Adverse reactions to paroxetine hydrochloride include nausea, drowsiness, dizziness, fatigue, diarrhea, and excessive sweating. It is contraindicated in people who are allergic to the product and the ingredients contained in it. Combination with monoamine oxidase inhibitors, methiopyridazine, pimozide and other drugs is prohibited. It is not suitable for pregnant and lactating women and children. Duloxetine Hydrochloride and Paroxetine Hydrochloride should be treated with a more appropriate medication based on the advice of a professional doctor.