Herpes zoster clinical presentation and treatment

  Herpes zoster, known as serpentine sores in Chinese medicine, is an acute infectious skin disease caused by the varicella-zoster virus. People who are not immune to this virus (especially children) develop chickenpox or subclinical infection after being infected for the first time. The virus remains latent for a long time in the neurons of the posterior root ganglion of the cremaster nerve and is reactivated when resistance is low or when the nerve becomes inflamed and necrotic, producing neuralgia and moving along the nerve fibers to the skin it innervates, producing a herpes. The disease occurs in spring and autumn and is more common in adults. The incidence increases significantly with age.  Herpes zoster may have prodromal symptoms such as fever, lethargy, general malaise, or no prodromal symptoms. Herpes zoster presents as unilateral clusters of erythema, papules, papules, and blisters with clear fluid and shiny, tense walls, and normal skin between the rashes. The disease is characterized by neuralgia, which is not parallel to the rash and may appear before the rash along with the lesions, which is often more intense in elderly patients, while some patients do not feel pain or feel itchy. The duration of the disease is usually 2 to 3 weeks, with temporary pale erythema or hyperpigmentation after the blisters have crusted off. It occurs in areas innervated by the intercostal, cervical, trigeminal and lumbosacral nerves.  There are some special types of herpes zoster, such as: herpes zoster with neuralgia without lesions, herpes zoster with incomplete herpes zoster with erythema and papules without blisters, herpes zoster with large blisters, herpes zoster with hemorrhagic blisters, herpes zoster with necrotic lesions and scarring after healing, and herpes zoster with localized typical herpes zoster followed by chickenpox-like rashes around the body. Ocular herpes zoster: conjunctivitis, ulcerative keratitis, and even blindness may occur; ear herpes zoster: herpes of the external auditory canal or tympanic membrane may occur, and if the geniculate ganglion is involved, facial palsy, otalgia, and herpes triad of the external auditory canal may occur, called Ramsay-Hunt syndrome; head and facial herpes zoster may cause viral encephalitis, meningitis, etc., and the lesions may fade for one month or more. The neuralgia that is still present above 1 month after the lesions have resolved is postherpetic neuralgia.  The first treatment requires early and adequate antiviral drugs (such as acyclovir, valacyclovir, famciclovir, etc.); nerve-nourishing drugs (vitamin B1, adenosine cobalamin, methylcobalamin, etc.); analgesic drugs (aminoglutethimide, acetaminophen, anandamide, etc.); tricyclic antidepressants are effective for post-herpetic neuralgia; anticonvulsant drugs (such as gabapentin capsules, pregabalin, etc.); for those who have difficulty in controlling drugs For severe pain that is difficult to be controlled by drugs, sensory nerve block therapy or nerve destruction therapy can be applied; acupuncture can also be used to reduce inflammation and relieve pain.