In general, the physical and chemical characteristics of semen cohesion is a minus sign, which means that the patient’s semen has increased in viscosity. Normally it takes 30 minutes for the sperm to completely liquefy, and the reason why this happens to the semen is related to two specific functions of the seminal vesicles and the prostate. The seminal vesicles are able to secrete a coagulase enzyme, and the prostate gland can also secrete a protein hydrolyzing enzyme. It takes about 20-30 minutes for semen to liquefy under the action of the protein hydrolyzing enzyme. And once there is a problem with the proteolytic hydrolase enzyme, then the liquefaction of semen will be problematic, so there will be an increase in semen cohesion. In addition, increased sperm cohesion may cause infertility, and it is recommended that patients go to the hospital for timely consultation and examination, and early treatment to avoid delay.