Patients with sinusitis are not advised to drink alcohol, and if they do, the following side effects may occur: First, the effect of alcohol leads to increased congestion of the nasal mucosa and local vasodilation, resulting in swelling of the nasal mucosa, especially hypertrophy of the inferior turbinates, leading to more pronounced nasal congestion, resulting in increased nasal secretions, making the symptoms associated with sinusitis more serious and detrimental to the recovery of the disease. Second, most patients with sinusitis need to apply antibiotic treatment, especially cephalosporins or penicillins, once the patient drinks alcohol, it may produce a disulfiram-like reaction, leading to the possibility that the patient may have a life-threatening condition. Third, due to the stimulation of alcohol, it is easy to induce patients to develop gastroesophageal reflux, and once gastroesophageal reflux occurs, the refluxed material enters the sinuses and nasal cavity, making sinusitis more aggravated. Patients with sinusitis are not clinically advised to drink alcohol, and drinking alcohol can be very harmful to the treatment of sinusitis.