Urine leukocytes 3 plus sign is generally more serious, usually suggests that the urinary system has an infection, interstitial nephritis, etc.; but there will also be false positives, such as female patients with leukorrhea contaminated specimens. Urine routine in the clinic is usually used to screen for urinary tract infections, when the white blood cells appear 3 plus, this situation is often more serious, usually may be combined with frequent urination, urinary urgency, urinary pain, fever, etc., the need for timely treatment. If possible, further bacterial culture examination can be carried out to determine the causative organisms before symptomatic treatment, for female patients, attention needs to be paid to exclude leukorrhea contamination of the specimen. Interstitial nephritis patients can also appear urine leukocytes 3 +, urine culture negative, no urinary discomfort symptoms, often combined with proteinuria, tubular urine, glycosuria, hypospadias, etc., the common cause of the disease due to drugs, generally more serious, need to be actively treated, the treatment is not timely, there may be an increase in creatinine, or even uremia. Urine leukocytes 3 plus, it is recommended that the regular hospital, under the guidance of the physician to improve the relevant examination, a clear diagnosis, targeted treatment.