Cold hands and feet in newborns are sometimes normal and sometimes caused by pathological factors. First, due to normal physiological phenomena, if the newborn baby does not wear enough clothes, or if the newborn baby is not covered enough when sleeping, this will lead to cold hands and feet, except for cold hands and feet, the newborn baby’s mental state is relatively good, the milk eating situation is normal, and the weight gain of the newborn baby is normal, no treatment is needed, as long as the newborn baby is kept warm in time. Secondly, cold hands and feet caused by various diseases, if various diseases cause disorders of peripheral circulation in newborns, which can lead to cold hands and feet. Newborns with severe bacterial infections causing septic shock will have obvious cold hands and feet, and capillary filling time will be significantly delayed, this situation should be timely anti-infection treatment.